medtech

Healthcare has traditionally focused on one-size fits-all medication to treat populations instead of tailoring treatments to individual patients. Recent advances in stem cell technology allow researchers to create disease models for personalized medicine. SEMI spoke with Thomas Pauwelyn, Postdoctoral Researcher at imec, about trends in medical technology innovation such as organ-on-chip devices and their applications. Pauwelyn shared his views ahead of his presentation at the SEMI SMART MedTech Forum, 13-14 November, in Hall B2 (Inspiration Hub) at SEMICON Europa, 12-15 November, 2019, in Munich, Germany. Join us at the event to meet experts from imec.xpand and other key industry influencers. Registration is open. Participation is free of charge for SEMICON Europa visitors. SEMI: What triggered the healthcare move from a one-size fits-all medication to treat populations to tailored treatments? What advancements allowed researchers to create models for personalized medicine? Pauwelyn: One of the main triggers for this transition is the inefficiency of the current healthcare system. The top 10 highest grossing drugs in the U.S. are effective for only between 1 in 25 to 1 in 4 patients. Not only do most medicines only help a small share of the patients, but they are often developed in classical clinical trials with predominantly western or male participants.Recent advances in stem cell technology allow researchers to create disease models for individual patients. In other words, researchers can reprogram cells from a patient’s skin or blood sample to various cell types, including cardiac or neuronal cells, through stem cell techniques. These samples reflect the traits that make a patient unique.However, patient-in-a-dish models expose cells to very artificial environments. So these models look very different from their counterparts in the body. Organ-on-chip systems address these issues by exposing cells to physiologically relevant conditions and create more mature models. SEMI: What is exactly an organ-on-chip? Pauwelyn: Organ-on-chip devices are microfluidic cell culture chips that can revolutionize the development of drugs and personalized treatments. These devices model the pathophysiological behavior of organs and tissues. Inside these chips, cell cultures are grown and exposed to conditions that better resemble in vivo microenvironment. Different organ models can be created by exposing different cell types to an engineered microenvironment. Common examples are the heart-on-chip, lung-on-chip, gut-on-chip or brain-on-chip.SEMI: Medical technology has made astonishing advances over the years. As new medical devices emerge, what are the main challenges?Pauwelyn: Meeting stringent regulatory requirements is one of the main challenges for medical devices. Technologies related to personalized medicine do not neatly fit in existing health technology assessments and reimbursement processes.In the case of organ-on-chip devices, there are challenges related to production, qualification and adoption. Increased standardization will also help scientists compare and interpret their findings. Currently, various research groups obtain different results from own organ-on-chip systems. These systems may be fabricated from different or exotic materials, expose cells to different microenvironments or rely on other cell models. Often, only a few devices are available for testing due to limited fabrication scalability.SEMI: What did imec do to overcome those challenges?Pauwelyn: imec turned to its expertise in chip design and technology to develop a novel organ-on-chip platform in close collaboration with Micronit Microtechnologies in the InForMed project funded by the ECSEL Joint Undertaking (ECSEL2014-2-662155). The platform’s main requirements were that it could reduce handling variability by microfluidic automation, be fabricated with conventional materials compatible with production upscaling, and produce high-quality electrical recordings of cellular activity. Another essential requirement was the compatibility of the device to the standard workflow of pharmaceutical research. The user interface is based a conventional 96-well plate, and peristaltic pumps are integrated into the device.SEMI: How does the CMOS-based microelectrode array work and where do you see potential for applications in the field of personalized medicine?The imec-developed CMOS-based microelectrode array is the sensor in our organ-on-chip system that monitors the cell culture. The sensor consists of 16,384 electrodes distributed over 16 independent microfluidic wells. It detects cellular activity down to the single-cell level, including intracellular action potentials or extracellular signals from electrically active cells or impedance caused by cells growing directly over the electrode.We believe this technology has great potential for developing miniaturized patient models in the lab. By using patient cells reprogrammed to the desired cell types through stem cell technologies, we can develop patient-on-chip systems. These systems would be able to predict which treatment is best suited for a specific patient or how drugs affect certain subpopulations.SEMI: What are your expectations for the SMART MedTech Forum at SEMICON Europa 2019 in Munich? Pauwelyn: The SMART MedTech Forum brings together an interesting mixture of researchers, entrepreneurs and stakeholders in the future of healthcare. I look forward to hearing their perspectives and to discuss how personalized medicine and MedTech will help tackle current challenges.SEMI: Can you share one prediction for the future of MedTech? Pauwelyn: I believe that MedTech in the future will help us tailor treatments to each patient. Doctors will have a wide arsenal of tools available to predict which treatment will deliver both the highest chance of success and the lowest chance of adverse reactions. One of these tools could be a human-patient-on-chip system. It would consist of interlinked organ-on-chip modules with patient-derived cell models. In this way, the reaction of patients to specific treatments could be predicted without ever exposing them to potentially harmful compounds.Dr. Thomas Pauwelyn currently is a post-doctoral researcher with an Innovation Mandate grant from VLAIO, investigating strategies to valorize the results from his research. Pauwelyn’s research focuses on developing novel organ-on-chip systems for predictive toxicology and drug development. He also investigates how organ-on-chip devices may help stratify patients and help enable personalized medicine. Pauwelyn has studied at KU Leuven, Belgium, since 2008. He earned his BSc in Bioscience Engineering specializing in Catalytic Technologies in 2011 and a Master’s in Nanoscience and Nanotechnology with the Bioscience Engineering option in 2013. He completed an IWT fellowship for a PhD at KU Leuven and imec’s Life Science Technologies group in 2018.Serena Brischetto is senior manager, marketing and communications, at SEMI Europe.

Back in February of this year, we launched SEMI Works™, a landmark SEMI program designed to grow and sustain the electronics industry talent pipeline from the ground up. But it was much more than a program launch. The introduction was a resounding statement of our passionate commitment to workforce development and its incontrovertible importance to the future of the microelectronics industry. No one’s passion for workforce development burns brighter than SEMI CEO Ajit Manocha’s. In April, he reiterated SEMI’s focus to make good on this commitment and laid out the broad outlines of SEMI Works. From the outset, our sights have been firmly fixed on execution. The National Science Foundation (NSF), a United States government agency that supports fundamental research and education in science and engineering, recently lent its support to SEMI Works with a $6 million investment to develop a scalable, sustainable apparatus to meet current and future talent requirements of the end-to-end electronics manufacturing industry. And more financial backing – this time from abroad – could well be in the offing. We are pressing ahead to develop the infrastructure to connect talent, industry and education providers at scale. We are expanding proven programs for exciting and engaging students in experiential learning opportunities at a young age. And we are paving the way to offer career and educational pathways through high school, college and adult and veteran training. Regional partners are essential to scaling these programs, and to date we have identified three regions for pilots to develop the infrastructure and business model that will be heartbeat of SEMI Works.Moore’s Law is losing steam, raising hard questions about the semiconductor industry’s ability to maintain its swift pace of innovation. The clarion call for chipmakers is to design ever smaller electronic circuits with higher processing power for devices with shrinking form factors. More computing muscle is crucial to advances in smart manufacturing, medtech, quantum computing, artificial intelligence (AI), 5G and the IoT – all technologies that generate and consume staggering amounts of data.Yet no obstacle to industry growth stands as tall as the brick wall of the talent shortage. A highly skilled workforce is essential to invention. As an industry, we’ll only be equal to the world’s greatest challenges by recruiting, training and retaining the best and brightest.At this critical juncture in what is the world’s most strategic industry, the public and private sectors must work collaboratively to leverage their collective strength to produce the talent required to power technology development today and well into the future.In 2020 SEMI will mark 50 years of facilitating collaborations to mint new technologies and markets. We are uniquely positioned, with our members, to lead what history may one day record as our most important effort to date, a push that could impact the world for decades to come. The industry needs a lasting solution to expand and sustain its talent pipeline. SEMI is taking decisive action with SEMI Works. Mike Russo is vice president of Global Industry Advocacy at SEMI.

Despite market saturation and stagnation saddling many business sectors, MEMS remains a shining star in the semiconductor industry. Opportunities in automotive, consumer electronics, mobile, medical are rising. What is supporting this industry growth? Who are the big players on the horizon?SEMI spoke with Dimitrios Damianos, Technology Market Analyst, Photonics, Sensing and Display division at Yole Développement, about MEMS market dynamics and future trends. Damianos shared his views ahead of his presentation at SEMI MEMS Imaging Sensors Summit, 25-27 September, 2019, at the WTC in Grenoble, France. Join us at the event to meet experts from Yole and many other key industry influencers. Registration is open.SEMI: MEMS and sensors is one of the healthiest industries not only in Europe but globally. Despite a global economic slowdown, the MEMS and sensors is still growing. What is fueling this growth?Damianos: The value of the global MEMS and sensor market will almost double from $48 billion in 2018 to $93 billion in 2024. In 2018 the MEMS and sensor market represented more than 10% of the total IC market, as more and more MEMS devices and sensors, such as MEMS, image sensors, and RF filters, are integrated in end products in consumer and automotive. In particular, the value of the MEMS-only market reached $11.6 billion in 2018, with consumer applications accounting for more than 60% of the total market. From 2019 to 2024 the MEMS market will grow 8.3% annually in value driven by pressure (for TPMS), RF (for V2X 5G communications), inertial (for ADAS) and future MEMS (such as pMUT for ultrasonic fingerprint) (Source: Status of the MEMS Industry report, Yole Développement, 2019). SEMI: How are MEMS shaping the semiconductor industry today? Damianos: MEMS have a make-smarter enabling capability. They are providing context for new applications and services in transportation, mobility, health, and security. Large companies such as Alibaba and Google are considering MEMS as a critical element in their business solution domains covering the upcoming smart home, smart campus, smart city and smart industry applications. MEMS have key features that correspond to these companies’ criteria for accuracy, small size (without performance degradation), low power and always on (e.g. microphones). Furthermore, with the advent of sensor fusion and edge computing, more sensor data can be processed, maximizing the qualitative and useful information about us and our surroundings. This has a huge impact in all markets, especially consumer.SEMI: MEMS foundries performed well thanks to the boom in industrial and medical applications. Who are the big players right now?Damianos: During 2018, all foundries saw their revenue increase. STMicroelectronics, Teledyne Dalsa, Silex, IMT, Micralyne and Philips Innovation Service are important MEMS foundry players that offer services for various MEMS devices used in medical and industrial markets, among others. On one hand, medical applications were driven mostly by microfluidics, flowmeters, pressure and inertial MEMS. On the other hand, industrial applications were driven by inkjet heads, microbolometers and pressure MEMS. The market prospect, however, is huge for RF MEMS and oscillators that will be used in next-generation 5G infrastructure. SEMI: What is the current status of MEMS for automotive applications? What are the related market drivers? Damianos: In automotive applications, accelerometers and pressure sensors still account for the lion’s share in units. Pressure sensors will grow at more than 8% with Tire Pressure Monitoring System (TPMS) implemented in Chinese vehicles in the near future. After 2019 and 2020, with the new Chinese standard, GB 2614, TPMS will become compulsory: 100% of all new vehicles will have TPMS. Also, automotive MEMS could grow quicker than the corresponding car market (currently at approximately 3%). The reason is a higher number of many different MEMS devices that are being integrated in cars, such as MEMS inertial measurement units (IMUs), TPMS, environmental MEMS for gas and particle monitoring in-cabin and microphones for hands-free voice commands.SEMI: After years of decline, the inkjet heads industry is growing again. What other segments are benefiting from MEMS technology applications? Can you name two examples?Damianos: RF MEMS (BAW filters) is also benefiting from applications in smartphones and will continue to benefit with the arrival of 5G. 5G means additional high frequency sub-6 GHz bands that can only be addressed by BAW filters. Moreover, new infrastructure approach using active antennas will create an expanding market for BAW.Another segment is inertial sensors. Inertial MEMS already have a high potential in wellness and fitness wearables and are gaining support for medical wearable applications to monitor patient activity, with the aim to prevent seizure in cases of epilepsy and other mental disorders. Compared to other types of sensors, MEMS is the golden technology for inertial sensors integrated into medical wearables. They are used for rehabilitation systems, activity trackers and assistance living/fall detection. Specifically, the IMU market will continue to grow for consumer and automotive applications as their price and form factor continue to shrink and they replace traditional standalone MEMS accelerometers and gyroscopes. However, the inertial sensor market will mostly grow for smartphone applications (mostly 6DOF, with 9DOF volumes being comparatively low).SEMI: Give us one prediction about the opportunities offered by the MEMS technology. Damianos: Sensor fusion is becoming more and more relevant since billions of MEMS sensors are made every year. The upcoming 5G revolution will make connectivity easier than ever, creating exponentially more data. To make these data meaningful, data processing is mandatory. Big data is an industry born of recent advancements in AI and machine learning, built upon and fueled by a wealth of new data from ever-expanding sensor applications. An upcoming trend is edge computing, with sensors and MEMS driving a new age of technology. Sensors are digitizing the human experience, and as the real and virtual worlds move closer together, it will be sensors that bind them, enabling new experiences for users everywhere. Running AI at the edge, coupled with sensor fusion, will open new applications for MEMS in audio, motion, olfactometry, and imaging. We also expect that new MEMS devices (microspeakers, ultrasonic fingerprint, pMUT) and piezoelectric MEMS technology could rejuvenate the MEMS market. SEMI: What are your expectations for SEMI MEMS Imaging Sensors Summit and why would you invite your peers to attend? Damianos: SEMI is organizing another very successful event, gathering experts from the Imaging and MEMS industries. We are at a turning point of innovation, with many technological advancements in AI, IoT, AR/VR, biometrics, and other areas where Imaging and MEMS technologies are paramount. Yole is excited to hear the thoughts of many high-profile experts on existing activities and future prospects within their organizations. If you are too, then it is an event that you shouldn’t miss!Dimitrios Damianos, Ph.D. is a Technology and Market Analyst in the Photonics, Sensing and Display division at Yole Développement (Yole). Damianos is a member of a Yole team that produces technology and market reports on the imaging industry including photonics and sensors. Damianos holds a MSc degree in Photonics from the University of Patras (Greece). After his research on theoretical and experimental quantum optics and laser light generation, Dimitrios pursued a Ph.D. in optical and electrical characterization of dielectric materials on silicon with applications in photovoltaics and image sensors, as well as SOI for microelectronics at Grenoble’s university (France). He has also authored and co-authored several scientific papers in international peer-reviewed journals. Learn more! Join the webinar on 5th September 2019. Registration is open! Serena Brischetto is a marketing and communications manager at SEMI Europe.

SEMI and imec are joining forces to drive innovation and deepen industry alignment on technology roadmaps and international standards while adding technology depth to SEMI’s five vertical application platforms including Smart Transportation, Smart MedTech and Smart Data.Under a Memorandum of Understanding announced today at ISS 2019, the two organizations have set their sights on bringing together key industry players to advance cutting-edge technologies including Internet of Things (IoT), artificial intelligence (AI) and machine learning that enable new capabilities across healthcare, automotive and semiconductor manufacturing. The partnership also aims to speed the time to better business results for SEMI and imec members and partners. SEMI brings to the partnership access to the $2 trillion global electronics manufacturing supply chain and imec its global research and development (R D) and innovation leadership in nanoelectronics and digital technologies.Under the MOU, the two organizations will co-produce SEMI Think Tanks, extend SEMI’s International Standards platform to non-CMOS technologies, identify and fill gaps in technology roadmaps, and tighten imec’s engagement with SEMI in European workforce development efforts.Bettina Weiss is Chief of Staff at SEMI.

Standing-room only keynote speeches. A future awash in data amassed by transformative technologies and applications, with semiconductors at their core. Smart everything: Cars, medicine, manufacturing, workforce, you name it. The sheer numbers impressed as a record lineup of SEMICON West keynote speakers offered a glowing portrait of the future: The semiconductor industry stands on the cusp of a breakout expansion. Standing and seated shoulder-to-shoulder in the packed-to-gills opening keynote, the audience learned, indeed, that the best was yet to come: “This is the best SEMICON West, ever,” observed SEMI CEO Ajit Manocha. Here’s a glimpse of the keynotes by the numbers, starting with the luckiest of all. 7 – The number of keynotes – among the brightest lights in technology – sharing their visions of the future through the lens of breakthrough technologies that are nearly ready to make their indelible mark. Dozens of expert panelists also weighed in at SEMICON West, the annual U.S. flagship microelectronics gathering in San Francisco. 90 – The percentage of all data ever generated has been created in just the past two years as the cloud mushrooms with tweets, texts, emails, Facebook posts, YouTube videos, medical records and all manner of business information, noted Bill Bottoms, president and CEO of Third Millennium Test Solutions. In the years ahead, an almost unimaginable wealth of data will require analysis by artificial intelligence (AI) embedded in semiconductors to enable applications that go well beyond smart. 12-18 – That’s how many months it will take for data volume to double, predicted John Kelly III, IBM’s Senior VP, Cognitive Solutions. And it will double again and again, every 12-18 months. Kelly foresees a scale of growth “that will dwarf previous eras of computing … the number of opportunities is enormous.” Kelly’s four decades in computing gave considerable weight to his point that “in the industry, there has never been a more exciting point in time than today.” First – Technology is being re-born. Using baseball lingo, several speakers noted that we are just in “the first inning,” “the top half of the first inning” or “the beginning of the first inning” to make clear in the most emphatic terms the duration of prosperity that lies ahead for the industry. AI embedded in chips and demand for real-time analysis of AI data will be its fuel. As SEMI Americas president Dave Anderson observed with a smile, “We all know how long baseball games can go.” Third – That’s the current wave of machine learning the world is now experiencing, according to Sandia National Laboratories’ Principal Member Conrad James. Computers are now capable of solving many increasingly complex problems on their own, with no human intervention necessarily required, he said. 1000x – As spectacularly fast as computing power already is today, the industry will need to double that the rate of performance in the years ahead, predicted Applied Materials president and CEO Gary Dickerson. Demand for this herculean processing capacity will spur a “tremendous focus on innovation” among SEMI members, their customers and their customers’ customers. 5 to 15 – The remarkable amount of silicon that power today’s mobile devices will be overshadowed by the chips – equivalent in computing capacity to 5 to 15 cell phones – that will be the engine of self-driving and other features in future automobiles, predicted Pierre Ferragu, New Street Research Managing Partner, during the SEMI Bulls and Bears session. Automobiles with this souped-up computing capacity will sell in the millions worldwide in the years ahead, generating never-before-seen opportunities for the chip industry, he noted. 10,000 – It’s not just cars. Ten thousand is the number of sensors that will be built just into the wings of new Airbus A380-1000 aircraft, AMD CTO Mark Papermaster explained during his keynote. 10 terabits – The staggering amount of Facebook data uploaded daily in to the cloud, Papermaster noted. 1 Trillion – SEMI’s 2020 forecast that the industry will reach $500 billion in revenues by 2020 was eclipsed by one analyst, speaking at the SEMI Market Symposium on the first day of the event, predicted that the industry would top $1 trillion in the foreseeable future. SEMI’s Manocha later added that $1 trillion in industry revenue is possible by 2030, “maybe sooner.” 1 (sexy) coda – Coders are hip and software applications are the apple of the world’s eye. Even the most casual mobile device user knows that software apps makes it whirl. But “hardware is becoming sexy again,” said Applied Materials’ Dickerson, adding that equipment and other semiconductor hardware developed by SEMI members will enable the next great wave of global economic growth. Scott Stevens, SEMI

For medtech applications to flourish, sensors need a supporting infrastructure that translates the data they harvest into actionable insights, says Qualcomm Life director of business development Gene Dantsker, who will speak about the future of digital healthcare in the Medtech program at SEMICON West. “Rarely can one device give a complete diagnosis,” he notes. “What’s missing is the integration of all the sensor data into prescriptive information.” The maturing medtech sector has developed to the point where sensors can now capture massive amounts of data, conveniently collected from people via mobile devices. The sector now has higher compute capacity to process the data, and improving software can produce actionable insight from the information. The next challenge is to seamlessly integrate these components into legacy medical systems without disrupting existing workflow. “Doctors and nurses don’t have time for disruptive technology – a new system has to be invisible and frictionless to use, with one or fewer buttons, no training and truly automatic Bluetooth-like pairing,” he says. “So device makers need to pack all system intelligence into the circuits and software.”Getting actionable healthcare information from sensors requires integration into the existing medical infrastructure. Source: Qualcomm LifeOne interesting example is United Healthcare’s use of the Qualcomm Life infrastructure to collect data from the fitness trackers of 350,000 patients. The insurance company then pays users $4 a day, or ~$1500 a year, for standing, walking six times a day and other behaviors that clinical evidence shows will both improve patient health and reduce healthcare costs. “It’s a perfect storm of motivations for all stakeholders,” he says.Next hot MEMS topics: Piezoelectric devices, environmental sensors, near-zero power standbyWith sensor technology continuing to evolve, look for coming innovations in MEMS in piezoelectric devices, environmental sensors and near zero-power standby devices, says Alissa Fitzgerald, Founder and Managing Member of A.M. Fitzgerald and Associates, who will provide an update on emerging sensor technologies in the MEMS program at SEMICON West.Piezoelectric devices can potentially be more stable and perhaps even easier to ramp to volume than capacitive ones, with AlN devices for microphones and ultrasonic sensors finding quick success. Now the maturing infrastructure for lead zirconate titantate (PZT) is enabling the scaling of production of higher performing piezo material with thin film deposition equipment from suppliers like Ulvac Technologies and Solmates and in foundry processes at Silex and STMicroelectronics, she notes.In academic research, where most new MEMS emerge, market interest is driving development of environmental sensors and zero-power standby devices. With demand for environmental monitoring growing, much work is focusing on technologies that improve the sensitivity, selectivity and time of response of gas and particulate sensors. Research and funding is also focusing on zero or near-zero power standby sensors, using open circuits that draw no power until a physical stimulus such as vibration or heat wakes them up.MEMS, however, likely won’t find as much of a market in autonomous vehicles as once thought. “While the automotive sensor market will need many optical sensors, MEMS players are competing with other optical and mechanical solutions,” says Fitzgerald. “And here the usual MEMS advantage of small size may not matter much, and the devices will have to meet the challenging automotive requirements for extreme ruggedness.”Paula Doe, SEMI