NBMC

At UES, Inc., our 300 employees faced a myriad of productivity, logistics, and communication challenges as we responded to COVID-19 yet we continued our work uninterrupted to deliver scientific research and technical expertise to the Department of Defense (DoD). We focus on several disciplines including materials science, aerospace power and propulsion, bio and nanoscale technologies, surface engineering, photonic and electronic technologies, additive manufacturing, and product development.UES is also an active member of SEMI Nano-Bio Material Consortium (NBMC), a public-private partnership with Air Force Research Laboratory (AFRL), and has been a part of the organization since its inception in 2013. Dr. Stephaney Shanks, Director of our newest division, Integrative Health and Performance Sciences (IHPS), is currently acting as the NBMC Governing Council Chairperson. IHPS is setting the standard for high-level research in the Air Force Research Laboratory’s 711th (711 Human Performance Wing) and beyond.Its areas of focus include advancing marker discovery in air and biofluids, sensor development, evaluating microbiomes for health and performance, toxicology, industrial hygiene, and high-throughput screening for genetic and chemical exposure. Most of our employees work at the Air Force Research Laboratory (AFRL) at Wright-Patterson Air Force Base, which is offsite of our corporate headquarters and product development labs.Here are some examples of how our COVID-19 response efforts have not only worked, but helped us thrive during this difficult period, enabling us to continue our vital research for the Air Force and our product innovation work in our corporate labs.1. Pursuing Research Projects to Support COVID-19 SolutionsStaffed primarily by scientists and engineers, UES holds a distinct position in supporting the fight against COVID-19. Our entire organization strongly supports finding solutions to the problems brought on by the pandemic to make life safer for everyone.With our AFRL partners and in our UES labs, we pursued new proposals and began projects to combat the pandemic’s problems. We’re developing rapid devices for detection of breath biomarkers that may indicate COVID-19 infection status to provide non-invasive testing capabilities. We are also pursuing point-of-care devices for real-time assessment of COVID-19 outside of the clinical environment, and we are developing models of the protein spikes of SARS-CoV-2 that could be used to further improve detection capabilities.UES also extended active research toward COVID-19 patient transport on cargo aircraft. We have been working with the 711 HPW to develop computational models to evaluate biological agent dispersal in cargo aircraft.UES is conducting research into the biological agent dispersal patterns in cargo aircraft. 2. Enacting an Effective Work-from-Home Policy and FormatBefore the pandemic, most of our employees did not have the option to regularly work remotely. However, by the end of March 2020, UES needed to respond to both DoD and Ohio government orders to stay at home. This presented new challenges. How do we keep laboratory/bench-based staff working? How do we keep all staff mentally engaged while teleworking?As luck would have it, we moved to Office 365 in February. That technology rollout proved to be a significant advantage in our COVID-19 response. Employees maximized their use of Microsoft Teams by sharing files, collaborating, using chat functions, and hosting video meetings. UES also utilized GoToMeeting for larger group meetings and real-time group file sharing/editing.By late March, our management team provided a tracker file in Excel format for all employees to document daily technical progress. This proved to be an excellent method to track projects, monitor staff COVID-19 symptoms or exposure, and record work location as the AFRL and UES labs began to allow small teams to return. This also kept managers in touch with employees on a weekly basis about ongoing work. It not only created extra layers of accountability, but also demonstrated progress and achievements week to week.Microsoft Office 365 has proved its usefulness to UES during the pandemic. 3. Offering Support to Employees and the CommunityThe overall wellness of our employees and the Dayton region is part of our mission at UES. As we resolved logistical issues and reshaped how we collaborated and delivered results, our leadership team began to focus on how to best support employees and our local community. A few activities supported this effort: We provided masks to all employees, along with an informational visual guide for best practices in wearing and caring for a mask. Safety has been a top priority for all employees. We started offering virtual Coffee Talks and Happy Hours. These company-wide online meetings gave employees a chance to reconnect and share concerns. We also shifted our Fitness Classes to an online format. We utilized our social media channels to engage with employees and share resources. We allocated community support to vulnerable populations (food banks and a domestic violence center). UES gave corporate donations, as well as shared non-financial ways to support the community with employees. This pandemic has brought plenty of challenges, but we're impressed by everyone's innovation and resilience. Every UES team member played an active role in adapting, not just to continue their daily work, but to be a part of the solution and support the community.UES used social media to share remote working tips with employees. Dr. Nina Joshi is president and CEO of UES, an award-winning innovative science and technology company based in Dayton, Ohio that provides its government and industry customers with superior research and development expertise, world-class technical support and value-added management services. A unique philosophy emphasizes passion for advancing science, dedication to superior service and commitment to enhancing careers. Contact the company here.

A multidisciplinary team of researchers is developing new methods to collect and analyze sweat for clues about how the body is functioning.Imagine if you could know the status of any molecule in your body without needing to get your blood drawn. Science fiction? Almost – but researchers at the University of Arizona are working on ways to do this by measuring molecules in sweat.When physicians take blood samples from patients, they send the samples to labs to be analyzed for biomarkers. These biological clues indicate everything from cholesterol levels to disease risks, and they can be used to monitor patient health or make diagnostic decisions. The same biomarkers also are found in sweat.Using $519,000 in funding from SEMI-NBMC (Nano-Bio Materials Consortium), Erin Ratcliff, University of Arizona materials science and engineering professor and head of the UArizona Laboratory for Interface Science of Printable Electronic Materials, is leading a project to develop new ways of collecting and analyzing the clues sweat has to offer. Ultimately, this work could allow physicians to use patient sweat samples in the same way they currently use blood samples, for a less invasive and more informative approach to establishing and monitoring patient health.“What’s unique about this is that we are combining biology and engineering expertise to develop a wearable device that will detect molecules in sweat, so you don’t have to get your blood drawn to know the health status of your immune system, your nervous system, indeed, any system in the body,” said co-investigator and sweat biomarker pioneer, Esther Sternberg, MD. “The goal, eventually, is to create a device that will provide physicians and health care providers the ability to monitor your health status continuously and in real-time without needing to draw blood.” Materials science and engineering professor Dr. Erin Ratcliff in her laboratory at the BIO5 Institute at the University of Arizona “We are pleased to sponsor and eager to complete this project with University of Arizona’s impressive team bridging the disciplines of engineering and life sciences,” notes Melissa Grupen-Shemansky, PhD, Chief Technology Officer and Executive Director of SEMI-NBMC. “A concerted interdisciplinary approach at the early stages of R D is relatively new and there is much learning on both sides. The UA team brings unique strengths in both areas and we are excited to be partnering and collaborating with them.”Ratcliff’s co-investigators are J. Ray Runyon, a research assistant professor in the Department of Environmental Science, and Sternberg, research director for the Andrew Weil Center for Integrative Medicine; director of the Institute on Place, Wellbeing, and Performance; and the Andrew Weil Inaugural Chair for Research in Integrative Medicine. Ratcliff and Sternberg are both members of the BIO5 Institute.Standardized Sample CollectionIn order to study sweat, researchers need to collect samples of it, and there are a number of ways to do so.“The obvious idea would be to make a patch that gets information from many pores at once, but the problem is that this creates a space between the patch and your skin, and you have to wait for it to fill up with sweat,” Ratcliff said. “We hypothesize that while you’re waiting, these molecules – the very molecules you’re trying to detect and analyze – are changing chemically.”The team’s first task is to develop new, continuous and hands-free collection devices that deliver high-quality, standardized sweat samples. This will allow health care professionals to gain a more holistic picture of a patient's bodily systems over an extended period, rather than the “snapshot” a blood draw can provide of a particular moment.Currently, sweat labs across the world are using different methods to collect samples, which limits researchers’ ability to compare data. Standardizing the collection method could provide researchers, including medical device developers, with a new degree of confidence in sweat sample data.“High-quality data, with respect to different target molecular biomarkers in sweat, requires that a high-quality sample be collected,” Runyon said. “This will be the first hands-free method that will truly take into account the interplay of the chemistry of sweat, the target biomarker and the device material.” University of Arizona student in classroom testing medtech devices Low-Level DetectionThe team is also developing methods for researchers to detect and analyze neuropeptides in the collected samples. Used by neurons to communicate with each other, these small molecules are involved in biological functions, including metabolism, reproduction and memory. Commercial wearable devices monitor metrics like heart rate, and some use sweat sensors to monitor dehydration level. Measuring neuropeptides, however, will allow researchers to zoom in millions of times closer to investigate stress and relaxation responses at the molecular level.“The idea is that your sweat is reflecting your nervous system – all of the neurotransmitters your body uses to signal between the brain and the rest of the body,” Ratcliff said. “Monitoring this biochemical response continually, over a 24-hour cycle, can inform us about the health of the wearer and also act as a diagnostic tool.”Meet Dr. Ratcliff and the University of Arizona team at FLEX in San Jose, Calif., February 23-26, 2020. Emily Dieckman is Editor at The University of Arizona. Republished with permission from the University of Arizona.

“A hundred years from now, someone’s going to look back and say, ‘Can you believe they waited until you got a disease, and then they did something?’” This observation from Dr. William Hait, the leader of Johnson Johnson’s External Innovation program, crisply sums up the SEMI Smart MedTech Summit, a two-day program at SEMICON Europa 2019, sponsored by GE Research and imecBenjamin Wiegand, PhD of Johnson Johnson, cited the quote in his opening presentation and added another pertinent question: “What if we could predict who was going to get a disease and then preempt it from happening?” Weigand’s conclusion is the first of six key takeaways from the summit.1. Accomplishing this vision could lead to a world without disease. Developing a disease-free world by exploring how the integration of advanced electronics and medical technology (MedTech) can enable new healthcare solutions is the very mission of the SEMI Smart MedTech Initiative. Various experts speaking at the MedTech Summit delved into a range of topics, from pan-European medical initiatives and artificial organs to new sensors and systems and start-ups’ need for funding and partners.2. All of us will have a digital twin (avatar), bringing together all relevant data that can impact our health and well-being.Several speakers illustrated the advantages of a digital human avatar that would start with an individual’s unique physical data and then be continuously updated with new data tracked by body-worn devices and from ongoing research findings. This would enable healthcare providers to extract insights and predict future physical performance or health issues.While, technologically, the avatar can already be constructed, the ability to make real changes to future human behavior is a significant outstanding question. Multiple speakers highlighted the various benefits of digital avatars at the MedTech Summit. 3. The MedTech sector’s need for cybersecurity looms large, as it does in every other digitally-driven, IOT-based framework.Further exploring the human-to-digital interface, Anthony Mathur of Bart’s Heart Center in the UK pointed to the importance of strict laws for safeguarding patient privacy, a cornerstone of healthcare digital policies, and the critical need for cybersecurity. He warned against an all-digital action network, citing the virus attack that shut down the UK’s National Health Service, rendering all patient records inaccessible for more than two weeks.4. MedTech devices, systems and other tools will radically change healthcare in the not-too-distant future.Almost every speaker touched on this point, including Franz Laermer of Bosch in his presentation The Future of Personalized Treatment. Laermer explored devices that will drive more patient-centric healthcare in areas including asthma therapy and molecular diagnostic testing and highlighted innovations in monitoring oncology therapies more effectively, less invasively and more accurately. Other presenters showcased their work in areas including silicon-based microfluidics, next-generation DNA sequencing and synthesis, lab-on-chip and cell arrays. 5. Startups and well-established companies will help advance digital tools and data to keep us healthier, happier and safer. Among the MedTech Summit highlights, several start-ups presented their business, financial and go-to-market plans. Notably, continuous glucose monitoring (CGM) is an especially active area of investment and innovation, as diabetes is among the world’s most widespread chronic diseases. The industry’s goal is to develop a non-invasive platform as a replacement for today’s prick-and-test approach to measuring blood sugar levels.6. Pan-European organizations are working to coordinate efforts and investments in digital healthcare. The European healthcare sector is large and diverse, as shown in the following slide provided by the organization MedTech Europe. Every country has its own legal framework, infrastructure, and health service structure medical technology companies must navigate. More than 27,000 medtech companies are located in Europe – 95% of them small to medium size businesses. Michael Stubin and Patrick Boisseau from MedTech Europe said concerted efforts to coordinate research and structural changes across the EU are underway to help spur medtech innovation and, with healthcare accounting for 10% of Europe's GDP, drive more market opportunity. This table shared by MedTech Europe points to the wide range of medical systems by country across the continent. Next StepsIs your company applying microelectronics innovations to change the way we approach medical care? If so, you’re invited to share your mission, roadmap and collaboration needs at a future MedTech Initiative Forum. For regular updates, join the MedTech interest list. In addition to the SEMI MedTech Initiative, our Nano-Bio Materials Consortium (NBMC) brings together scientists, engineers and business development professionals from industry, government and universities to collaboratively initiate research and development of electronic technologies to improve human performance monitoring and performance augmentation. Find out more at www.semi.org/collaborate/communities/NBMC.Michael Ciesinski is the Vice President of Technology Communities at SEMI.

SEMI’s annual FLEX Conference Exhibition returns to Monterey, California, February 18-21, 2019, bringing together nearly 100 speakers on the major developments at the leading edge of printed/flexible/hybrid sensors and electronics technology.The maturing technology for smarter sensors, in a wider range of flexible formats, is enabling new opportunities across a wide range of applications, from healthcare to agriculture. And that means sensor suppliers need to connect with a broader range of users to build the next generation of innovative outside-the-box solutions. SEMI gathers the flexible/hybrid integration supply chain, leading researchers and potential customers at this annual event to help advance the sector.Collaborative efforts for sensors emerging markets: global health, faster crop development, military monitoringThere’s huge potential for smarter, more accessible sensor systems to detect infectious diseases and aid decision-making for community health workers around the globe, but new technologies and manufacturing methods alone will not be enough to meet the needs of these resource-constrained environments, argues Arunan Skandarajah, program officer at the Bill and Melinda Gates Foundation. He’ll introduce the foundation’s funding and partnering priorities for sensing and imaging for diagnostics and decision support and discuss potential paths forward for development.Recent advances in plant genomics and high-throughput phenotyping have big potential to enable faster development of crop varieties that better withstand adverse conditions – but that will depend on getting fast feedback from sensor data from the field. There’s immediate need for robust, high-efficiency, low-cost sensor technologies to collect on-the-ground microclimate and resource-use data from tractor-based sensors to field scanners, says Nadia Shakoor, Danforth Plant Science Center. She’ll discuss the sensors researchers need to develop high-yielding, energy- efficient crops that are resilient to variable climates.Military interest in biosensor patches to monitor human physiology and performance, and other sensor solutions for flexible imaging and point-of-care diagnostics, are also drivers of collaborative research between industry and universities. The Nano-Bio Materials Consortium (NBMC), a SEMI strategic association partnership with the Air Force Research Lab, will offer a workshop to discuss its potential needs, and how to get involved in its development program to create an integrated suite of nano-bio materials and production technology. Progress in scaling printed/hybrid flexible electronics manufacturing technologyThe maturing manufacturing supply chain continues to make progress towards scaling volume manufacturing of higher performance products, with recent innovations in materials and assembly technologies.Cal Poly researchers will report results from the recent FlexTech benchmark study of the flexible hybrid electronic industry. The study looks at the current state of maturity of the technology, its manufacturing processes, and its main applications while projecting the roadmap for future development. The study covers passives, sensors, batteries, antennas, speakers, PV and energy harvesting, and flexible hybrid integration.Catch up on new process development capabilities and recent work at the NextFlex Flexible Hybrid Electronics Manufacturing Institute’s San Jose Technology Hub for prototyping and pilot manufacturing. The institute has been adding engineers and projects as it looks towards the next generation of technology for sector growth. Innovations in scalable assembly of thin die on flexible substratesSeveral companies will update on recent progress developing solutions for the industrial-scale, high-yield assembly of fragile thinned die on to flexing substrates. American Semiconductor reports new automated assembly capacity for flip chip die attach and interconnect for devices with up to 100 I/Os and 100um pitch pads. The company also notes that it now has flexible Bluetooth ICs from two major suppliers available in semiconductor-on-polymer chip-scale packages, finally enabling improved wireless capacity for flexible hybrid systems.CEA-Leti will present its latest developments in flip chip bonding of thin bare die on flex. It uses gold stud bumps on the die, with 150°C thermocompression bonding to PEN Film. The researchers have also developed a wafer-level die process that thins and encapsulates die before removing them from the carrier wafer. systeMECH will also present its results for direct die placement of 300nm die on flexible polyester. Innovations in materials for easier processing, higher performanceDevelopments in substrates and processing may now enable use of photonics for laser patterning and flash curing on flexible substrates. Brewer Science will report developments on new polymers that can be quickly and cleanly etched with the mid-UV wavelengths commonly used for laser drilling and etching on printed circuit boards, bringing this improved performance to printed electronics as well. The polymers can be processed at less than 200°C with desirable qualities for substrates, adhesives, protective layers and the like for many electronics applications.Novacentrix will update on improvements in photonic curing equipment for fast heating to enable the use of high-temperature solders without damaging low-temperature substrates. Atotech will report results from its multiyear initiative to develop lower temperature solder pastes for better performance than SAC-based materials on a variety of substrates. Printed graphene and carbon nanotubes find applications in sensors and RF devicesBonbouton will introduce its commercial smart insole using a printed graphene sensor to monitor skin temperature to detect early signs of foot ulcers in diabetic patients. The company inkjet-prints graphene oxide followed by thermal reduction to fabricate graphene supercapacitor electrodes for temperature and pressure sensing.C2Sense will update on its development of carbon nanotube gas sensors to monitor food condition to prevent waste. The sensitized carbon nanotubes selectively detect ethylene from fruit or ammonia from chicken to accurately track the condition of the foods as they pass through the supply chain. Georgia Tech will report results of printing not only sensors from carbon nanotube ink but even RF and mm-wave diodes and transistors for high-frequency, long-range, low-cost RFIDs. Innovations in display materialsMaterials for flexible displays continue to see innovations – from solutions for foldable displays to plenty of new options for improved transparent conductive films and force-sensitive films. Solotech will introduce a cross-inked polymer that it says offers both high hardness and excellent foldability as a reliable covering for foldable/bendable displays. Atotech will describe its development of selective electroless copper deposition for metal mesh and TFT electrode patterns for touch screens to eliminate the need for costly mask and etching steps after deposition. Chasm Advanced Materials suggests hybrids of the conductive metals and carbon nanotubes offer a promising alternative for flexible transparent conductive films.C3Nano reports on nanowire ink, fused after printing, for flexible transparent conductors. Peratech will report on its printable pressure touch technology that it describes as high-resolution and low-cost for better localized, force-sensitive touch. Jabil will share the results of its evaluations of five of the available printed force-sensitive sensors. E Ink will introduce new capabilities for its electrophoretic display technology – it’s now possible to write on it with a magnetic stylus, and there’s a variable transmission version for electronic windows. Next generation technologies from universities and startupsResearchers from major research institutions and startups will talk about developments in flexible/printed/hybrid electronics including innovations in biological/electronics interfaces, via skin or neurons, and demonstrations of piezoelectric and better stretchable circuits. Emerging technologies for biosensors and human/machine skin interfaces Georgia Tech researchers will detail their electrical interface with human skin for wireless control of a remote-control car and a wheelchair by electrical signals from the body. They’ve developed a flexible elastomer skin patch patterned with thin film metal/polymer nanostructures made by CMOS processes, and metal pads compatible with conventional reflow soldering. Other Georgia Tech researchers will report their work on better cochlear implants made of encapsulated polymer printed with conductive microcoils for pulsed micro-magnetic stimulation that can focus more tightly on specific areas of auditory neurons. Seoul National University will introduce its flexible organic artificial nerves that can activate an insect’s leg muscle. Researchers there have devised a pressure sensor connected to a ring oscillator that converts the pressure signal into voltage pulses, which are then integrated by a transistor into a signal that replicates a post-synaptic current to communicate with the biological nerves.Epicore Biosystems will report on its advances in manufacturing and packaging technology that enable its skin-interface electronics and microfluidics systems in thin stretchable format to continuously monitor electrical, acoustic and biochemical signals. The technology is now entering commercial development with industrial partners. GE Global Research will update on its field testing of sweat-sensing devices to monitor hydration. Emerging technologies for piezoelectric actuators and improved stretchable sensors and circuits PARC will report on audio speakers made of PVD piezoelectric film on polyimide with inkjet-printed flexible hybrid operating circuits, and Novasentis will talk about its piezoelectric electroactive polymer for different kinds of vibrations for wristband notifications. UTC will share its learnings from deploying large numbers of stretchable flexible hybrid sensors conformably over large areas on aerospace and infrastructure assets to sense temperature, vibration, strain and damage for critical safety.The Air Force Research Lab reports promising results for stretchable circuits made with liquid metals, which maintain their high conductivity even when stretched. Silent Sensors will discuss its printed flexible manufacturing technology for low-cost, stretchable energy storage and piezoelectric energy harvesting for monitoring the condition of automobile tires.By Heidi Hoffman, senior director of technology community marketing, SEMI