SMART MedTech Virtual Workshop Series

Biography

Biography

Recent developments in both biological data acquisition and analysis provide new opportunities for data driven modeling of the health state of an organism. In this talk we explore geometric ideas and manifold learning methods for analyzing such data sets. In one example we examine the evolution of temperature patterns generated by telemetry data collected from healthy and infected Collaborative Cross mice challenged with Salmonella typhimurium. We visualize the interruption in circadian patterns and characterize the severity of infection within three days after exposure. This work was conducted in collaboration with David Threadgill and Helena Andrews-Polymenis of Texas A&M University.

Biography

A key to making digital care delivery easier is to augment biometric monitoring with predictive & prescriptive analytics. Optimized algorithms can efficiently tie together fragmented data sources, such as wearables & medical records. More importantly, they lay the foundation for intuitive workflows that guide clinical staff through effective triage & medical interventions.

Biography

The tissue engineered medical product (TEMP) industry has been held back historically by a lack of scalability, challenges with product consistency, and high final product costs. Over the last three decades, cutting edge science in the space has continued to advance while manufacturing tools and equipment specific to the needs of the field has lagged behind in development. To propel TEMP technologies into the commercial market, automation and sensor technologies need to be developed and implemented to make practical the scalable, consistent, cost-effective manufacturing of TEMPs. BioFabUSA is program of the Advanced Regenerative Manufacturing Institute (ARMI), an industry-led, member-driven, non-profit organization funded by the department of defense dedicated manufacturing of engineered tissues and tissue-related technologies. ARMI | BioFabUSA coordinates technology development projects that crosscut manufacturing areas in raw materials, automation, equipment, software, sensors and measurement tools, data management, preservation, processes, quality systems, and other pertinent elements of tissue engineered medical product manufacturing. With the combined effort of the ARMI membership, ARMI drives impactful advanced research and development activities that enable the development of a scalable, modular, automated and closed platform for the fabrication of TEMPs. This platform relies heavily on the integration of sensors and automation necessary to advance manufacturing technology development and demonstration, paving the way for compressed timelines for process design and development, as well as commercial, GMP-compliant manufacturing.

Biography

With an ongoing shift from managing disease towards the inclusion of maintaining health the world has seen the rise of increasingly sophisticated body monitoring and analytics. These tools are aiming to empower the individual to better navigate own health. They are also seeking to generate powerful insights towards the detection of subclinical symptoms or processes via existing and novel digital biomarkers. In that context a topic that is receiving increasing interest is the modulation of human physiology around an individual ‘baseline’ in everyday life and the dynamic around that. Today, there is more and more fully contextualised and truly long-term physiological data becoming available that allows deeper insights into the response of the human body to our behaviour, exposed environment or health events per se. This provides real life data in an unprecedented way. Insights emerging from that are fascinating, sometimes surprising and increasingly instructional.

This talk will provide an overview of where we have come from, what we are currently at and what’s unfolding in the convergence of different domains towards such more integrated and holistic health mapping and new opportunities in real word evidence driven clinical trials.