Exploring Enabling Approaches for Precision Medicine throughout the Drug Development Process
Abstract:
The drug development ecosystem increasingly relies on an integrated digital-device network to inform decisions from discovery through post-market surveillance. Central to this paradigm is the prioritized use of organ-on-a-chip (OoC) platforms in the earliest screening stages, enabling more faithful recapitulation of human biology and improving predictive power for safety and efficacy. We propose a targeted OoC strategy that seeds early discovery with tissue- and organ-level readouts (liver, blood–brain barrier, kidney, gut barrier, heart, and lung interfaces) to capture human-relevant metabolism, barrier function, electrophysiology, and systemic crosstalk. By coupling OoC-derived signals with in silico models, translational biology, and conventional 2D assays, we create a cohesive, human-centric screening funnel that informs target validation, lead optimization, and go/no-go decisions with greater translational fidelity
Biography:
Dr. Laura Matz is the Chief Science and Technology Officer for Merck KGaA, Darmstadt, Germany, driving innovation and digitalization across the 3 business sectors, Life Sciences, Healthcare, and Electronics. Serving as an Executive Vice President within Merck KGaA, Darmstadt, Germany, she is responsible for the corporate innovation teams, including new digital business models. In addition, Laura is CEO of the data sharing platform company, Athinia®, which focuses on enabling secure data sharing within the semiconductor ecosystem. She possesses 20 years of experience in semiconductor manufacturing and a decade of experience in running semiconductor materials businesses.
Prior to becoming the Chief Science and Technology Officer, she was a Senior Vice President within EMD Electronics (previously Versum Materials and Air Products Electronics division). She has always been a key contributor to the growth in semiconductor materials, driving a strong R&D presence to enable business growth.
Laura is a strong advocate for young talent in science and engineering. As a leader, she builds teams to find innovative solutions to the problems facing humanity and implement them with the discipline and rigor to create the greatest impact. In 2023, she joined SEMI Impact for Skills as a board member, a governance program to support upskilling and reskilling, to attract new talent, and to unlock EU and national/regional funding. In addition, she is a board member of AIChE (American Institute of Chemical Engineers), a leading organization for chemical engineering professionals.
Laura has a Ph.D. in Analytical Chemistry from Washington State University and an undergraduate degree from the Indiana University of Pennsylvania.