Session 10: FPE Applications
Integration and Scalable Manufacturing of Printed Microfluidic Devices
Wednesday, June 21, 2017
11:30 AM - 11:50 AM
Advances in microfluidics technology are effectively revolutionizing bio-analytical procedures, with example applications including enzymatic analysis (e.g., biomarker assays), DNA analysis (e.g., polymerase chain reactions and high-throughput sequencing), and proteomics. Emerging applications include biochips used for clinical pathology, in particular the immediate point-of-care diagnosis of diseases, along with for wearable and point-of-care health status and performance assessment. While microfluidics incorporate specific fluidic architectures at the micro/nanoscale to achieve sample acquisition, prep, and delivery functions, broader system functionality is managed through the integration of multiple subsystem components including valve and pumping mechanisms, flow metering, and analyte detection. Traditional microfluidic systems employed a range of microelectromechanical components to manage system functionality, with the drawback that full system integration was difficult to achieve via high throughput manufacturing methods, thereby limiting cost competitiveness for many applications. For single use wearable or disposable medical devices, microfluidic analytical systems fabricated by scalable print and roll-to-roll manufacturing processes offer a compelling approach to integrate the required system functionality, control, and intelligence via low-cost, high throughput, industry relevant process platforms. We will describe substrate, materials, processes, and scalable production platforms suitable for the integration of multifunctional microfluidic devices and systems, with demonstrated results for applications in biomarker sample acquisition and detection from sweat in a wearable device configuration.
Jeff Morse is the Managing Director of the National Nanomanufacturing Network, part of the NSF Center for Hierarchical Manufacturing, at the University of Massachusetts, Amherst. Previously, Jeff was a Senior Scientist in the Center for Micro and Nano Technology at Lawrence Livermore National Laboratory. He received his BS (1983) and MS (1985) Degrees in Electrical Engineering from the University of Massachusetts, and a PhD (1992) in Electrical Engineering from Stanford University. His interests and expertise includes semiconductor devices, advanced micro/nanofabrication processes, microelectromechanical systems (MEMS), biosensors, microfluidics, and micro-power sources.
University of Massachusetts, Amherst